MOSCHONAS, Nicholas

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MOSCHONAS, Nicholas

Professor Emeritus

School of Medicine

University of Patras, Greece

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EDUCATION

  • 1979-1982: EMBO Postdoctoral Fellow, Division of Gene Structure & Expression, Director: Richard A. Flavell, National Institute of Medical Research, Medical Research Council, Mill Hill, London, UK
  • 1975-1979: Graduate student, PhD candidate supported by a fellowship of the State Fellowships Foundation, Greece; Dept. of Biology, U. of Athens and Dept of Cellular & Developmental Biology, the Biological Laboratories, Harvard U., MA, USA (Supervisor: Prof. Fotis C Kafatos)
  • 1970-1975: BSc in Biology, Dept. of Biology, U. of Patras

RESEARCH ACTIVITIES

  • Research activities in medical molecular genetics and functional genomics with the aim to understand the architecture and the biological impact of the genetic information in health and disease using cell culture and animal models combined with integrated omics and bioinformatics approaches.
  • Total number of publications and review articles: 92, Average Impact Factor: 6.2, Citations: 2898,  h-index: 26, i10-index:42.
  • > 70 invited talks in congress and scientific meetings.

PREVIOUS EMPLOYMENT

  • 2021-present: Affiliated Scientist, FORTH/ICE-HT, GR
  • 2020-present: Professor Emeritus of Biology and Medical Molecular Genetics, Medical School, University of Patras, GR, (n_moschonas@med.upatras.gr, cell. Phone: 00306977783551)
  • 2006-2020: Professor of Biology and Medical Molecular Genetics, Medical School, University of Patras, GR; 2009-2020: Director of the Laboratory of General Biology, Medical School, U Patras, GR
  • 2014-2020: Collaborating Professor Member of the Institute of Chemical Engineering Science-FORTH Patras, GR.
  • 1998-2006: Professor of Human Molecular Genetics, Dept. of Biology, University of Crete, GR (Vice-Chairman of the Department for the period: 2000-04); 1993-1988: Associate Professor, Department of Biology, U. of Crete, GR; 1988-1993: Assistant Professor, Department  of  Biology, U. of Crete, GR; 1984-1988: Lecturer, Dept. of Biology, U. of Crete, GR; 1984-2006: Head of the Laboratory of Human Molec. Genetics, Dept. of Biology, U. of Crete, GR.
  • 1983-2006 (joint appointment): Research Scientist, Institute of Molecular Biology and Biotechnology (IMBB), Foundation of Research and Technology (FORTH), Heraklion, Crete, Greece.

PARTICIPATION IN RESEARCH PROJECTS

Coordinator or Principal Investigator of 10 international and 24 national competitive research grants.

OTHER PROFESSIONAL ACTIVITIES

Teaching

(1983-present): Full-semester under-and/or postgraduate-level courses in Human Molecular Genetics, Genomics and Molecular Cell Biology [Med. School, U. Patras (2006-present), Dept. of Biology, U. of Crete 1984-2006 as faculty member]; AUTH, ΝKUA, DUTH, U. Crete (as Invited Instructor, since 2008).
1984-present: Academic Supervisor of 13 PhD, 20 MSc theses, and 20 Diploma theses.
1990-present: 80 participations as member of the advisory & PhD and MS dissertation examination committees.

Academic Appoinments (recent and indicative)

  • Chairman of the Basic Medical Sciences I Division, Medical School, U. Patras (2018-2020).
  • Member of the General Assembly, Medical School, U. Patras (2016-2020).
  • Director of the Dept. of General Biolgy, (2009-2020).
  • National Delegate of Greece at the EU FP7 Theme “Cooperation-HEALTH” (2005-2010).
  • Deputy Member of the National Council for Research & Technology-GR (2005-2009).
  • Member of the Bioethics Committee of the Hellenique Orthodox Church (2002-present).
  • HUGO/Genome Database (GDB) Editor for Human Chromosome 10 (1995-2004); Senior Editor for HC10, elected by the Human Genome Organisation/Human Genome Mapping Committee, 1999- 2004.
  • Member of the ad hoc Committee for the National Strategic Reference Framework (NSRF) for Research, Technical Development & Innovation-GR (Section: Health) (2008-09).
  • Deputy Chair of the Department of Biology, University of Crete (2000-04).
  • National Expert at the Human Genome Analysis Programme of the CAN-MED Biomedicine and Health Research Programme, EC-DGXII,  1992- 1997.
  • Member of the Research Committee (1999-02), and the Senate of the University of Crete (1988-90).

SELECTED PUBLICATIONS

  • Moshonas, N.K., de Boer, E., Grosveld, F.G., Dahl, H.H.M., Wright, S., Shewmaker, C.K., Flavell, R. A (1981). Structure and expression of a cloned beta-thalassaemic globin gene. Nucleic Acids Res. 9, 4391-4401
  • Busslinger, M., Moschonas, N. and Flavell, R.A (1981). Beta+ thalassaemia: Aberrant splicing results from a single point mutation in an intron. Cell 27, 289-298.
  • Flavell, R.A., Bud, H., Bullman, H., Dahl, H., de Boer, E., de Lange, T., Groffen, J., Grosveld, F., Grosveld, G., Kioussis, D., Moschonas, N. and Shewmaker, C. (1981). Globin gene expression in vivo and in vitro. In: Organization and Expression of Globin Genes.. Eds. G. Stamatoyannopoulos and A.W. Nienhuis, 2nd Conference on Hemoglobin Switching, Airlie, Virginia, U.S.A. Alan R. Liss Inc., New York, pp. 119-126 (review).
  • Moschonas, N.K., de Boer, E., Flavell, R.A. (1982). The DNA sequence of the 5’ flanking region of the human beta globin gene: evolutionary conservation and polymorphic differences. Nucleic Acids Res. 10, 2109-2120.
  • Rodakis, G., Moschonas, N. and Kafatos, F.C. (1982). Evolution of a Multigene Family of Chorion Proteins in Silkmoths. Cell. Biol., 2, 554-563.
  • Rodakis, G., Moschonas, Regier, J. and Kafatos, F.C. (1983). The B Multigene family of Chorion Proteins in Saturniid Silkmoths. Mol. Evol., 19, 322-332.
  • Moschonas, N.K, Thireos, G. and Kafatos, F.C (1988). Evolution of Chorion Structural Genes and Regulatory Mechanisms in Two Wild Silkmoths: A Preliminary Analysis. Mol. Evol. 27, 187-193.
  • Mavrothalassitis, G., Tzimagiorgis, G., Mitsialis, A., Zannis, V., Plaitakis, A., Papamatheakis, J and Moschonas, N.K (1988). Isolation and characterization of cDNA clones encoding human liver glutamate dehydrogenase: Evidence for a small gene family. Natl. Acad. Sci. USA, 85, 3494-3498.
  • Mamalaki, A. and Moschonas, N.K. (1990). Aberrance and modification of alpha-1 and alpha-2 globin gene expression in human and mouse erythroleukemia cells. Acta Haematol., 84, 30-37.
  • Mamalaki, A., Anagnou, N. & Moschonas, N. (1990). Developmental and inducible patterns of human theta-1-globin gene expression in embryonic/fetal and adult erythroid cells. J. of Haematol. 35, 251-257.
  • Tzimagiorgis, G., Adamson, M.C., Kozak, C.A. and Moschonas, N.K (1991). Chromosomal mapping of glutamate dehydrogenase gene sequences to mouse chromosomes 7 and 14. Genomics, 10, 83-88.
  • Michaelidis, Th., Tzimagiorgis, G., Moschonas, N.K. & Papamatheakis, J. (1993). The human glutamate dehydrogenase (GLUD) gene family: gene structure and organization. Genomics, 16, 150-160.
  • Deloukas, P., Dauwerse, J.G., Moschonas, N.K., van Ommen, G.J.B. and van Loon, A.P.G.M. (1993). Three human glutamate dehydrogenase genes (GLUD1, GLUDP2 and GLUDP3) genes are located on chromosome 10q, but are not closely physically linked. Genomics, 17, 676-681.
  • Moschonas, N.K., ..Lubyova, B., Manifava, M., Deloukas, P., van Loon, G-J.B. and M. Kapsetaki (1993). Dinucleotide repeat polymorphism (D10S608) adjacent to the GLUD1 locus. Molec. Genet. 2, 11, 1981.
  • Kapsetaki, M., Kokkinaki, M., Angelicheva, D., Lubyova, B., Mavraki, H., Argyrokastritis, A., Ferguson-Smith, M., Lush, M. and Moschonas, N.K. (1994). The EUROGEM map of human chromosome 10. In, N.K.Spurr et al.: European Gene Mapping Project (EUROGEM): Genetic maps based on the CEPH reference families. J. Hum. Genet. 2,193-252.
  • Pucyriov, A.T., Chroniary, K and Moschonas, N.K. (1995). Normalized cDNA library from human erythroleukemia cells. Biol. (Mosc), 29, 1, 58-61.
  • Anagnou, P., Perez-Stable, C., Gelinas, G., Constantini, F., ..Costeas, T., Moschonas, N.K. and Stamatoyannopoulos, G (1995). Sequences located 3’ to the brakepoint of the HPFH-3 deletion exhibit enhancer activity and can modify the developmental expression of the human fetal A-gamma-globin gene in transgenic mice. J. Biol. Chem.,270, (17), 10256-10263.
  • Moschonas, N.K., Spurr, N.K. and Mao, J-I (1996). Report of the First International Workshop on Human Chromosome 10 mapping 1995. Cytogenet Cell Genet. 72, 99-112.
  • Kritis, A.A., Argyrokastritis, A., Moschonas, N.K., Power, S., Katrakili, N., Zannis, V.I., Cereghini, S. and Talianidis, I (1996). Isolation and characterisation of a novel isoform for the human hepatocyte nuclear factor 4. Gene 173, 275-280.
  • Cox, S.A., .. Povey, S., Rebello, M., Kapsetaki, M., Moschonas, N.K., Grzeschik, K.-H., Otto, M., Dixon, M., Sudworth, H. E., Kooy, F., Wright, A., Teague, P., Terrenato, L., Gal, A., Mueller-Myhsok, B., Cann, H.M. and Spurr, N.K. (1996). European Gene Mapping Project (EUROGEM): Breakpoint panels for human chromosomes based on the CEPH reference families. Hum. Genet.  60, 447-486.
  • Liu, D., Pavlopoulos, E., .. Moschonas, N. and Mavrothalassitis, G (1997). ERF: Genomic organization, chromosomal localization and promoter analysis of the human and the mouse genes. Oncogene 14:1445-1451.
  • Shashidharan, P., .Moschonas, N.K. and Plaitakis, A. (1997). Nerve tissue-specific human glutamate dehydrogenase that is thermolabile and highly regulated by ADP. Neurochem. 68:1804-1811.
  • Marzella, R., Kokkinaki, M.A., Kapsetaki, M., Ricco, A., Argyrokastritis, A., Kamakari, S., Sarafidou, T., Archidiacono, N., Roussou, A., Pasparaki, A., Rocchi, M. and Moschonas, N.K. (1997). Map integration at human chromosome 10: molecular and cytogenetic analysis of a chromosome-specific somatic cell hybrid panel and genomic clones, based on a well-supported genetic map. Cell Genet. 79:257-265
  • Mavrogiannis L, Argyrokastritis A, ..Dermitzakis E, Sarafidou T, Patsalis PC, and Moschonas NK (2001). ZNF232: Structure and expression analysis of a novel human C2H2 zinc finger gene, member of the SCAN/LeR domain subfamily. Biophys. Acta, Apr 16;1518(3):300-305
  • Bentley, D.R, Deloukas P, … Moschonas N.K, … Sarafidou T, .. et al., (2001). The Physical Maps for Sequencing Human Chromosomes 1, 6, 9, 10, 13, 20 and X. Nature, 409, 942 – 943.
  • Pavlopoulos, E., Pitsouli, C., Klueg, KM., .., Moschonas, NK., and Delidakis, C. (2001). neuralised encodes a peripheral membrane protein involved in Delta signalling and endocytosis. Develop Cell, 1, 807-816
  • Morante-Redolat JM., ..Gesk S., Sarafidou T., Mautner V-F, … Deloukas P, Moschonas N K, Michelucci R,  Siebert R, Nobile C, Pérez-Tur J,  López de Munain A. (2002). Mutations in the LGI1/Epitempin gene on 10q24 cause autosomal dominant lateral temporal epilepsy. Human Molec Genet. 11(9), 1119-1128.
  • Staub E., Perez-Tur J., Siebert R., Nobile C., Moschonas N.K., Deloukas P. and Hinzmann B. (2002). The novel EPTP repeat defines a superfamily of proteins with implications in epileptic disorders. Trends Biochem Scie. 27 (9) 441-444
  • Sarafidou T, . … Baker E, Kokkinaki M, … Deloukas P, Sutherland G R, Kutche K, Moschonas N K, Siebert R, Gecz J. (2004). Folate-sensitive fragile site FRA10A is due to an expansion of a CGG-repeat in a novel gene FRA10AC1, encoding a nuclear protein. Genomics 84(1): 69-81
  • Deloukas P., Earthrowl M.E….. Kokkinaki, M.,….Sarafidou T., Sehra H.K.,….Lovering, R.C., Moschonas NK., Siebert R., Fechtel K., Bentley D., …Smith DR., and Rogers J. (2004). The DNA sequence and comparative analysis of human chromosome 10. Nature, 429, 375 – 381
  • Mizi A, Zouros E, Moschonas N & Rodakis GC (2005). The complete maternal and paternal mitochondrial genomes of the Mediterranean mussel Mytilus galloprovincialis: Implications for the Doubly Uniparental Inheritance mode of Mol Biol Evol 22(4): 952-967
  • Kartsaki E, Spanaki C, .. Moschonas N, Macdonald M, Plaitakis A. (2006). Late-onset and typical Huntington disease families from Crete have distinct genetic origins. Int J Mol Med. 17(2):335-46.
  • Ayerdi-Izquierdo, A, Stavrides, G., ….Sarafidou, T., Hinzmann, B., Moschonas, N., Siebert, R., Deloukas, P., Nobile, C., Pérez-Tur, J. (2006). Genetic analysis of the LGI/Epitempin gene family in sporadic and familial lateral temporal lobe epilepsy. Epil Res Aug;70(2-3):118-26.
  • Martinez L, Underhill P, .., Moschonas N, ..Cavalli-Sforza L, Herrera RJ. (2007). Paleolithic Y-haplogroup heritage predominates in a Cretan highland plateau. J. Hum Genet. 15, 485–493
  • Athanasiadis G, …Moschonas N, Chaabani H, Moral P (2007). The X chromosome Alu insertions as a tool for human population genetics: data from European and African human groups. J. Hum Genet. 15, 578–583.
  • Koutelou, E, Sato S, ..Kokkinaki M, Conaway RC, Conaway J W, and Moschonas N K. (2007). Neuralized-like 1 (Neurl1) Targeted to the Plasma Membrane by N-Myristoylation Regulates the Notch Ligand Jagged1. J Biol. Chem. 283, 3846-3853
  • Athanasiadis G, Esteban E, .. Moschonas N, . Moral P. (2010). Different evolutionary histories of the coagulation factor VII gene in human populations? Ann Hum Genet. Jan;74(1):34-45.
  • Sarri C, Douzgou S, . Sarafidou T, ..Moschonas NK, Petersen MB (2011). Complex distal 10q rearrangement in a girl with mild intellectual disability: Follow up of the patient and review of the literature of non-acrocentric satellite chromosomes. Am J Med Genet Part A 155:2841–2854.
  • Klapa, MI, Tsafou,K., Theodoridis E., Tsakalidis A. and Nicholas K. Moschonas (2013). Reconstruction of the experimentally supported human protein interactome: what can we learn? BMC Syst Biol. 2013 Oct 2;7(1):96.
  • Sarafidou T and Moschonas N (2017). Chromosome 10. Encyclopedia of Life Sciences (eLS), Edit. J.Wiley & Sons. Ltd: Chichester, DOI: 10.1002/9780470015902.a0005819.pub3, pp:1-43.
  • van Rijswijk M, … Klapa M I, …Le Corguillé G, Moschonas N K, ..Reczko M, ..Steinbeck C. (2017). The future of metabolomics in ELIXIR. F1000Research 2017, 6 (ELIXIR):1649 Last updated: 18 Sep 2017.
  • Gioutlakis A, Klapa MI, and Moschonas NK. (2017). PICKLE 2.0: A human protein-protein interaction meta-database employing data integration via genetic information ontology. PLoS ONE PONE-D-17-20180R1; DOI: 10.1371/journal.pone.0186039.
  • Papadimitropoulos M, Anastasopoulou S, Galiopoulou E, Manousopoulou A, Bicciato S, Garbis S, Sarafidou Th. Klapa MI, and Moscohonas N.K. (2018). Integrated high-throughput biomolecular analyses ofFRA10AC1altered expression in a human cell model. Eur J Hum Genet: 50th Society of Human Genetics Conf., https://doi.org/10.1038/s41431-018-0247-7, P16.32D.
  • Tsare, A. Gioutlakis, M. I. Klapa, N. K. Moschonas (2019). Investigating the genetic architecture of hypertension through combined analysis of genome-wide association studies (GWAS) data and the human protein interaction network. Eur J Hum Genet27, 1–688 (2019). 51st European Society of Human Genetics Conference. https://doi.org/10.1038/s41431-019-0404-7; P16.39C.
  • GN Dimitrakopoulos, A Gioutlakis, MI Klapa, NK Moschonas (2020) Evaluating the expansion of the experimentally determined human protein interactome using the PICKLE meta-database Eur J Hum Genet 27: 1705.
  • GN Dimitrakopoulos, MI Klapa, NK Moschonas (2021). PICKLE 3.0: enriching the human meta-database with the mouse protein interactome extended viamouse–human orthology. Bioinformatics, Volume 37, Issue 1, 1 January 2021, pages 145–146.