Achievement

Proved : (i) that intrapleural inj. of liposomal drugs results in tumor targeting and enhanced bioavailability (in vitro and in vivo), and (ii) Synergistic anticancer effect of doxorubicin-liposomes and CAPP

Achieved synthesis of novel: (i) multifunctional ligand-targeted magnetoliposomes and (ii) Doxorubicin-arsonoliposomes with enhanced activity towards in vitro models of melanoma and lung-cancer

REFERENCES
Marazioti, A., Papadia, K., Giannou, A., Stathopoulos, G.T., Antimisiaris, S.G. 2019 Prolonged retention of liposomes in the pleural cavity of normal mice and high tumor distribution in mice with malignant pleural effusion, after intrapleural injection Open Access International Journal of Nanomedicine, 14, pp. 3773-3784

Skouras, A., Papadia, K., Mourtas, S., Klepetsanis, P., Antimisiaris, S.G. 2018 Multifunctional doxorubicin-loaded magnetoliposomes with active and magnetic targeting properties. European Journal of Pharmaceutical Sciences, 123, pp. 162-172

Zagana, P., Mourtas, S., Basta, A., Antimisiaris, S.G. 2020 Preparation, physicochemical properties, and in vitro toxicity towards cancer cells of novel types of arsonoliposomes Open Access Pharmaceutics 12(4),327

Pefani-Antimisiari, K., Athanasopoulos, D.K., Marazioti, A., (…), Svarnas, P., Antimisiaris, S.G. 2021 Synergistic effect of cold atmospheric pressure plasma and free or liposomal doxorubicin on melanoma cells Open Access, Scientific Reports 11(1),14788