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Nikos Karamanos

Nikos Karamanos

Professor - Department of Chemistry

University of Patras

Tel.: +30 2610-997915   Email:

Last updated: February 2015


1988: PhD in Chemistry (Biochemistry), Univ. of Patras, Greece
1984: Diploma in Chemistry (grade A), Univ. of Patras, Greece


Previous Employment/Occupation:

Present since 2003: Professor, Dept. of Chemistry, Univ. of Patras
1999-2003: Associate Professor, Dept. of Chemistry, Univ. of Patras, Greece
1993-1999: Assistant Professor, Dept. of Chemistry, Univ. of Patras, Greece
1990-1993: Lecturer, Dept. of Chemistry, Univ. of Patras, Greece
1987-1989 & 1991-1999: Pre - and Postdoctoral Research fellow (annual periods, total 3-years) Karolinska Institute, School of Medicine, Stockholm, Sweden


Research Activities:

  • Matrix pathobiology, cell signaling, molecular targeting, preclinical evaluation of drugs and toxicological assessment of nanomaterilas at cellular level.
  • Implication of proteoglycans, glycosaminoglycans, metalloproteinases and acidic glycoproteins in tissue organization, pathogenesis and progression of various disorders, such as cancer, atherosclerosis and inflammation.
  • Signal transduction pathways mediating the gene expression and biosynthesis of matrix molecules by various normal or cancer cells. Regulation of gene expression by cytokines and growth factors are also studied.
  • Development of highly sensitive bioanalytical methods and their application to identify macromolecular structure-activity relationship in physiological and pathological conditions as well as in disease diagnosis, monitoring and pharmacokinetic studies.


Participation in Research Projects:

Principal Investigator or Collaborator in National and (GSRT-PENED, THALIS, HRAKLEITOS, KESY, etc), International (EU Leonardo, EU Comet, FEBS-ALC, FP7 etc) and Industrial research projects in the areas of biotechnology, oncology, safety analysis/cytotoxilogy and pharmacokinetics.



  • Over 250 publications in international peer review journals, book series and full proceeding and over 30 book chapters.
  • Editor of the International book edition: Extracellular Matrix: Pathobiology and Signaling, De Gruyter, Berlin/Boston (2013).
  • 3 books on biomolecules structure-function, biochemical analysis, immunoassays and advanced biochemistry.
  • Over 250 abstracts in proceedings of International and Hellenic scientific conferences.


Conference Participation/Attendance:

Over 70 invited and plenary lectures in International and National scientific conferences and Universities/ Research Institutes, among them FECTS-2004 Italy, FEBS-2010 Sweden, Gordon Research Conference on proteoglycans-USA 2012, Ludwig Cancer Institute-Uppsala 2011, Med. School-Reims Univ. France 2012 etc


Organization of workshops, meetings and conferences:

  • Chairman of two European conferences (Euro Advanced HPLC course, 1992 and on Microseparation techniques, 1998).
  • Scientific Secretary of the International conference FECTS-2000.
  • Chairman of the FEBS advanced lecture courses on Matrix Pathobiology, Signaling and Molecular Targets (FEBS-MPST 2007, 2009, 2011 & 2013).
  • Scientific Secretary and International Contact Person of the 33rd FEBS Congress and 11th IUBMB Conference, Athens, 2008.
  • Chairman of the 60th Biochemistry & Molecular Biology Conference, Athens, 2009.
  • Member of the organizing/scientific committees in more than 15 scientific conferences on matrix biology and connective tissue research, medicinal and clinical chemistry-clinical biochemistry.


Guest editor /Coordinator of special and thematic issues:

  • Special issue: CE of carbohydrates (Analysis of carbohydrate macromolecules by capillary electrophoresis: glycoproteins, proteogycans/glycosaminoglycans and glycolipids), Biomedical chromatography, Wiley Interscience, Vol. 16 (2002).
  • Special issue: Solid phase assays for molecules with biopharmaceutical importance, Journal of Pharmaceutical & Biomedical Analysis, Elsevier, Vol. 34 (2004).
  • Special issue: Matrix Pathobiology, Signaling and Molecular Targets, Connective Tissue Research (2008) Vol. 49, issues 2 & 3.
  • MiniReview Series co-cordinator in FEBS J: one Series in 2010, two Series in 2011 and in 2014.
  • Special issues: Proteoglycans signaling targeting & therapeutics, FEBS J 2013 & Matrix-mediated cell behaviour and properties, BBB 2014.


Awards / Honours:

A number of awards has been conferred by various Scientific Societies, among them the Hellenic Society of Biochemical & Molecular Biology Society, Hellenic Society for Microbiology and Biopathology, Paediatrics, Society for Anticancer Research, Danish Technological Institute, Neurological Society and the Federation of European Connective Tissue Societies.


Teaching Activities-Trainees:

Undergraduate teaching: Lectures in Biochemistry I, Clinical Chemistry, Biology and Chemistry of Organic Natural Products.
Graduate teaching: Courses Masters & Ph.D.: Lectures in Advanced Biochemistry I and II, Molecular Biology & Molecular Biotechnology, Clinical Biochemistry, Organic & Biochemical Analysis.
Trainees: Supervisor for 13 PhD and 25 MSc awarded titles, 5 PhD and 5 MSc under progress.


Professional Activities/Affiliations:

  • Reviewer in a number (>25) of peer review scientific journal in the areas of Biochemistry, Biochemical Analysis, Cell and Molecular Biology, Cancer, Matrix Pathobiochemistry, Anticancer Agents, Molecular Targeted Therapy and Cardiovascular Research.
  • Member of the editorial boards of 'The Journal of Biological. Chemistry, PloS ONE (academic editor), FEBS Journal (advisory editorial board), Matrix Biology, Current Medicinal Chemistry, Biomedical Chromatography, Current Pharmaceutical Analysis, Current Chemical Biology, Data Sets in Biology (area cell biology), J Paediatric Biochemistry, Chromatographia (2003-2009).
  • Contact person in Federation of European Connective Tissue Societies (FECTS) and coordinator of the Hellenic Research Club for Connective Tissue and Matrix Biology (2003-2010 & 2011).
  • President of the Hellenic Society of Biochemistry and Molecular Biology (2006-2007), Secretary General (2004-2005) and Vice-President (2008-present).
  • European Union Expert, FP7, theme "Health" (2007-2009).
  • Head of the Department of Chemistry, University of Patras (2007-2011).
  • Member of the Quality assurance unit of the University of Patras (2011-present).
  • Vice-rector of academic & international affairs of the University of Patras (2014-present).


Selected Representative Publications:

For a complete list of publications visit:

  • Ch. Gialeli C, AD. Theocharis N.K. Karamanos. Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting. FEBS J. 2011 Jan; 278(1):16-27.
  • E.G. Barbounis, M.N. Tzatzarakis, A.K. Alegaki, A. Kokkinaki, N. Karamanos, A. Tsakalof, A.M. Tsatsakis. Assessment of PCBs exposure in human hair using double focusing high resolution mass spectrometry and single quadrupole mass spectrometry. Toxicol Lett. 2011 Aug 22. [Epub ahead of print].
  • C.J. Malavaki, A.P. Asimakopoulou, F.N. Lamari, A.D. Theocharis, G.N. Tzanakakis, N.K. Karamanos. "Capillary electrophoresis for the quality control of chondroitin sulfates in raw materials and formulations". Anal Biochem, 374 (2008) 213-220.
  • X.N. Stahtea, A.E. Roussidis, I. Kanakis, G.N. Tzanakakis, G. Chalkiadakis, D. Mavroudis, D. Kletsas, N.K. Karamanos. "Imatinib inhibits colorectal cancer cell growth and suppresses stromal-induced growth stimulation, MT1-MMP expression and pro-M-MP2 activation". Int. J. Cancer 121 (12) (2007) 2808-2814.
  • A.D. Theocharis, C. Seidel, M. Borset, K. Dobra, V. Baykov, V. Labropoulou, I. Kanakis, E. Dalas, N.K. Karamanos, A. Sundan, A. Hjerpe. "Serglycin constitutively secreted by myeloma plasma cells is a potent inhibitor of bone mineralization in vitro". J. Biol. Chem. 281 (2006) 35116-35128.
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