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Antimisiaris Sophia

Antimisiaris Sophia Professor
Department of Pharmacy, School of Health Sciences, University of Patras, Greece

Tel. : +30 2610-962 332    Email:

Last updated: February 2013


1980-1984: Department of Pharmacy, School of Health Sciences, University of Athens, Greece, Degree: Bpharm (8.4/10)
1984-1988: Department of Pharmacy, School of Health Sciences, University of Athens, Greece, Degree: PhD (Biopharmaceutics)
1997: Pharmacist License


Previous Employment/Occupation:

2002-2009: Associate Professor, Department of Pharmacy, University of Patras, Greece.
1993-2002: Assistant Professor, Department of Pharmacy, University of Patras, Greece.
1992-1993: Visiting Professor, School of Pharmacy, University of London, UK
1989-1993: Lecturer, Department of Pharmacy, University of Patras, Greece.
1988-1989 / 1990: PostDoc fellow / Visiting Professor, School of Pharmacy, University of South California (USC), Los Angeles, USA.


Research Activities:

  • Biopharmaceutics and Pharmacokinetics: Improving Drug Biodistribution and Pharmacokinetics through Advances Drug Delivery System Design
  • Nanomedicines: Liposomal or Nanoparticulate systems for Controlled Drug (or Vaccine) Delivery and/or Targeting
  • Application of novel lipid vesicles (Arsonoliposomes) in Anticancer / Antiparasitic Therapeutics
  • Novel Controlled-(Release)-Drug-Releasing Stents
  • Ocular, Alveolar and Vaginal Drug Delivery
  • Application of Liposomes in Analytical Techniques
  • Nanoparticles for Alzheimers Disease / Targeting the Brain


Participation in Research Projects:

1989-: Participation as coordinator and/or PI in 2 National (GSRT & Ministry of Education) funded and 8 European programs, including Marie-Curie mobility - training project (FP6), Socrates mobility and Intensive Program Training Projects (LLLP), Integrated Project (FP6-Health & FP7-NMP), Interreg program and industry-funded projects.



78 Papers in peer-reviewed journals, 20 Invited Papers & Reviews or Chapters in Book Series, 111 Abstracts in proceeding of international conferences, 6 Papers in Greek Scientific Journals, 1 World patent, 1 PCT, 1 US, 1 EPO and 4 Greek patents.


Conference Participation/Attendance:

Participation in more than 76 International conferences or educational workshops, and more than 23 National conferences, Invited speaker in more than 30 National and International scientific or educational meetings / workshops.



1989- Undergraduate Program (Pharmacy Dept): Biopharmaceutics and Pharmacokinetics (+Practical course) Pharmaceutical Technology: Pre-Formulation / Design and Preparation of Drug Formulation.(+Practical course).
1995 - Postgraduate Program (Pharmacy Dept): Applied Pharmacokinetics, Determination of Drugs in Biological Fluids, Pharmaceutical Statistics, Advanced-Novel Pharmaceutical Formulations (Liquid, Semi-Solid, Solid).
2000 - Postgraduate Program (School of Medicine): Pharmacokinetic Modeling / Modulating Drug Pharmacokinetics by Advanced Drug Delivery Systems For the Socrates Educational Program "Novel Drug Delivery Systems: 10-day Workshop entitled: Liposome Technology and Applications in Therapeutics/Nanomedicines (1997-98, 1999-2000, 2003, 2008).


Professional Activities:

Referee of 40 Pharmaceutical and related Scientific journals. Participation in three Research Proposal Evaluator panels (& Panel Rapporateur), European Commission, Research Directorate, 2004-2008 (2) and 2008-2013 (1). Evaluator for the Spanish Ministry of Development and Research (after invitation), Evaluatores, 2006 & 2008, Israel Research Foundation (2010), Norwegian Centre of Excellence (2011-2012) and other international funding societies. President of the Western-Greece Committee for evaluation of Pharmacy Technicians (2001-). Evaluator for the National Foundation of Drugs (EOF) for Clinical Studies and Formulation Bioequivalence Studies (2000-). Member of Scientific Committee of the International Conference of European Association of Pharma Biotechnology [EAPB] (2004). Member of Scientific Advisory Board Europe, of New Drugs, official publication of EAPB (2004). Associate Editor of J. Biomedical Nanotechnology. Invited editor of JBN Special Issue on Nanomedicines (2008). Member of Editorial Board of Journal of Pharmacy and BioAllied Sciences (2010) and Journal of Drug Delivery (2010). Member of the Senate, Univ. of Patras (2004-5). Member of the Graduate Studies committee, Dept. of Pharmacy, Univ. of Patras (1998-). Coordinator of the Socrates mobility Program for the Dept. of Pharmacy, Univ. of Patras (1998-).


Professional Affiliations:

  • Panhellenic Association of Pharmacists
  • APGI/APV (Association de Pharmacie Galenique Industrielle)
  • European Federation of Pharmaceutical Scientists (EUFEPS)
  • Controlled Release Society (CRS)
  • CRS -Greek Chapter [President 1999-2001]
  • International Liposome Society (ILS)
  • AAPS -American Association of Pharmaceutical Scientists
  • Galenos Network for novel Drug delivery Exploitation and Education



1980-1984: Scholarships from Greek State Scholarships’ Foundation (IKY) for outstanding performance during undergraduate studies (Ranking in top 5% of class).
2011: Award for best poster at the EuroNanoForum, 2011, May 30-June 1, Budapest, Hungary.


Selected Publications:

  • G. Koromila, G. Michanetzis, Y.F. Missirlis, S.G.Antimisiaris*, Heparin incorporating liposomes as a delivery system of heparin from PET-covered metallic stents: Effect on haemocompatibility, Biomaterials, 27:12, 2525-2533, 2006
  • M. Zaru, S. Mourtas, P. Klepetsanis, A.M. Fadda and S.G.Antimisiaris*, Liposomes for drug delivery to the lungs after nebulization. Eur. J. Pharmaceutics & Biopharmaceutics, 67 (3), pp. 655-666, 2007
  • G. Besson, M. Caron, S. Lekana-Douki Etenna, A. Mintsa-Ndong, S. Mourtas, B. Salle, C.De Giuli Morghen, P. LaColla, S. Antimisiaris M. Kazanji "Protective properties of non-nucleoside reverse transcriptase inhibitor (MC1220) incorporated into liposome against intravaginal challenge of Rhesus Macaques with RT SHIV", Virology 405 (1), 225-233, 2010
  • S. Mourtas, M. Canovi, C. Zona, D. Aurilia, A. Niarakis, B. La Ferla, M. Salmona, F. Nicotra, M. Gobbi, S. G. Antimisiaris*, Curcumin-decorated nanoliposomes with very high affinity for amyloid-b1-42 peptide, Biomaterials, 32: 6, 1635-1645, 2011
  • Canovi, M., Markoutsa, E., Lazar, A.N., Pampalakis, G., Clemente, C., Re, F., Sesana, S., (...), Antimisiaris*, S.G .The binding affinity of anti-A1-42 MAb-decorated nanoliposomes to A1-42 peptides in vitro and to amyloid deposits in post-mortem tissue. Biomaterials, 32 (23), pp. 5489-5497, 2011
  • A.Skouras, S. Mourtas, E. Markoutsa, M-C. De Goltstein, C Wallon, S Catoen, SG. Antimisiaris*. USPIO encapsulating nanoliposomes with high entrapping efficiency, stability and magnetic properties. Nanomedicine: Nanotechnology, Biology and Medicine, 7 (5) , pp. 572-579, 2011.
  • E. Markoutsa, K. Papadia, C. Clemente, O. Flores, S.G. Antimisiaris*. Anti-A MAb and dually-decorated nanoliposomes: Effect of A1-42 peptides on interaction with hCMEC/D3 cells, EJPB 81 (1) , pp. 49-56, 2012.
  • V. Ntimenou, A. Fahr, and SG. Antimisiaris*. Elastic Vesicles for Transdermal Drug Delivery of Hydrophilic Drugs: A Comparison of Important Physicochemical Characteristics of Different Vesicle Types J. Biomed. Nanotechnol. 8, 613-623 2012
  • P. Svarnas, S. H. Matrali, K. Gazeli, Sp. Aleiferis, F. Clement, S. G. Antimisiaris*. Atmospheric-pressure guided streamers for liposomal membrane disruption. Applied Physics Letters, Applied Physics Letters 101 (26) , art. no. 264103 2012
  • A. Lazar, S Mourtas, I Youssef, C Parizot, A Dauphin, B Delatour, SG Antimisiaris, C Duyckaerts. Curcumin-conjugated nanoliposomes with high affinity for A deposits: possible applications to Alzheimer disease Nanomedicine: Nanotechnology, Biology, and Medicine, on-line 2013
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