PICKLE: Standardized meta-database of the human and mouse protein interaction network
The Protein InteraCtion KnowLedgebasE (PICKLE; www.pickle.gr) is a meta-database of the human and recently mouse experimentally-determined direct protein-protein interaction (PPI) network, integrating major primary datasets over the genetic information ontology network of the UniProtKB/Swiss-Prot reviewed human complete proteome (RHCP). This ontology-based structure constitutes PICKLE the only PPI meta-database enabling the evaluation of the human interactome expansion at both the protein and gene levels through comparison of its successive releases. PICKLE has been co-developed by University of Patras (Prof. N. K. Moschonas’ research team) and FORTH/ICE-HT (Metabolic Engineering & Systems Biology Laboratory, Dr. M. I. Klapa). PICKLE has been supported by ELIXIR-GR structural funding, is is included in the ELIXIR bio.tools repository and can be accessed through https://bio.tools/PICKLE.
- Dimitrakopoulos GN, Klapa MI, Moschonas NK. (2021). PICKLE 3.0: Enriching the human Meta-database with the mouse protein interactome extended via mouse-human orthology. Bioinformatics, 37, 1, 145-146.
- Gioutlakis A, Klapa MI, Moschonas NK. (2017). PICKLE 2.0: A human protein-protein interaction meta-database employing data integration via genetic information ontology. PLoS ONE 12(10): e0186039.
- Klapa MI, Tsafou K, Theodoridis E, Tsakalidis A, Moschonas NK. (2013). Reconstruction of the experimentally supported human protein interactome: what can we learn? BMC Syst. Biol. 7:96.