Ημερομηνία: 24-06-2026, 16:00
Τοποθεσία: Αίθουσα Συνεδρίων ΙΤΕ/ΙΕΧΜΗ
Μεταγωγή σήματος και ενδοκυτταρική διακίνηση στην βιολογία των αγγείων: Επιπτώσεις στον καρκίνο και στη νόσο Αλτσχάιμερ
SEMINARS
| Ομιλητής:
|
Dr. Σάββας Χριστοφορίδης, Διευθυντής Ινστιτούτου Βιοϊατρικών Ερευνών (ΙΒΕ-ΙΤΕ), και
Καθηγητής Βιολογικής Χημείας, Τμήμα Ιατρικής, Πανεπιστήμιο Ιωαννίνων |
| Θέμα: | Μεταγωγή σήματος και ενδοκυτταρική διακίνηση στην βιολογία των αγγείων: Επιπτώσεις στον καρκίνο και στη νόσο Αλτσχάιμερ |
| Περίληψη: | Endothelial cells play pivotal role in vascular physiology and are implicated in life threatening diseases, including cardiovascular diseases and angiogenesis in cancer, as well in neurodegenerative diseases, such as Alzheimer’s and Parkinson. Given that these are highly diverse diseases, with distinct outcomes, a central question in the field is: “what are the common etiological mechanisms?”. Interestingly, several key molecules playing fundamental role in these diseases are stored in specialized endothelial secretory organelles known as Weibel Palade bodies (WPBs). Upon cellular activation, WPBs secrete their cargo into the blood circulation. A critical trigger of this process is VEGF, whose main receptor, VEGFR2, undergoes endocytosis into endosomes, a process that is essential for regulating its signalling output. Our group investigates the spatio-temporal orchestration between endocytosis, signalling and exocytosis in endothelial cells and their implications in vascular physiology and related diseases. To achieve these objectives, we employ high-end microscopy techniques (i.e. super resolution microscopy, total internal reflection fluorescence microscopy, electron microscopy and quantitative image analysis algorithms), as well as functional assays. These approaches allow us to uncover the molecular and physical connections between endocytosis, signalling and exocytosis and decipher their role in diseases that are seemingly totally different, such as cancer and Alzheimer’s. Overall, by studying membrane trafficking and signalling, we provide proof of concept that by manipulating endocytosis we can control a broad spectrum of serious vascular-related diseases, from cardiovascular disorders to cancer and Alzheimer’s. |
| Σύντομο βιογραφικό: | Savvas Christoforidis studied Chemistry (AUTH, 1990, degree Suma cum Laude) and got his PhD in Biological Chemistry, Department of Medicine, University of Ioannina (1995) and moved to EMBL/Heidelberg/Germany for Post-doctoral studies in Cell and Molecular Biology, as a Marie Curie fellow. In 2000 he received a Marie Curie Return Fellowship, as an independent researcher. In 2001 he was elected Lecturer of Biological Chemistry, Department of Medicine University of Ioannina, where he now holds a Professor position. In 2002, Savvas Christoforidis received the EMBO Young Investigator award. He has participated in 37 successful grant applications, in 18 of which he was the PI. Four of these grants were European, i.e. Marie Curie Individual Return grant (2000-2001), two European Integrated Projects and the MSCA PF Horizon Europe grant (2023-2025). His work has been published in high impact Journals, such as Nature, Nature Cell Biology, Cell, Mol Cell, Journal of Cell Biology, EMBO Journal, Journal of Cell Science, and has received over 4,500 citations (in Scopus, excluding self-citations). The main research interest of the group is to understand the role of intracellular vesicular transport (endocytosis and exocytosis) in vascular physiology and the implications in vascular diseases. |
Πληροφορίες για την τοποθεσία
Αίθουσα Συνεδρίων ΙΤΕ/ΙΕΧΜΗ
Οδός Σταδίου, Πλατάνι, GR-26504, Πάτρα
Διοργανωτής
ΙΤΕ/ΙΕΧΜΗ
Οδός Σταδίου, Πλατάνι
www.iceht.forth.gr
Έναρξη: 24-06-2026, 16:00