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Systems Biology Studies of Dr. Klapa's group featured in BMC Systems Biology and evaluated in Faculty of 1000

The research work of Dr. Klapa's group on Metabolic Engineering and Systems Biology at the Institute of Chemical Engineering Sciences of the Foundation of Research and Technology-Hellas (FORTH/ICE-HT) was recently honored by two significant distinctions. Specifically:

1. The recently published paper of Dr. Klapa's group:

Kanani H., Dutta B., and Klapa M. I. (2010) "Individual vs. combinatorial effect of elevated CO2 conditions and salinity stress on Arabidopsis thaliana liquid cultures: Comparing the early molecular response using time-series transcriptomic and metabolomic analyses", BMC Systems Biology, 4:177 (published on December 29, 2010)


was in the "Featured Articles" of the BMC Systems Biology, journal for one month since its publication. Only 5% of the published papers with respect to originality and importance to the field of the journal make it to this group.

In this work, the researchers used integrated "omic" analyses to investigate the molecular response of A. thaliana liquid cultures to salinity stress alone and in the presence of elevated CO2 conditions. The results indicated that elevated CO2 slightly alleviates the negative effects of salt on the growth of the plants by providing additional metabolic resources. Taking into consideration the particular interest of the two investigated perturbations in plant biotechnology, enhanced understanding of the molecular physiology of the plants under these conditions could lead to the design of novel metabolic engineering strategies to increase the resistance of commercial crops to salinity stress.

In this context, this paper was the basis for an ESPA-Collaboration proposal that was recently selected for funding by GSRT.

2. The Faculty of 1000 poster entry of a collaborative study of the Metabolic Engineering and Systems Biology Laboratory of FORTH/ICE-HT, headed by Dr. Klapa, and the groups of Profs. Flytzanis and Koumoundouros of the Department of Biology, University of Patras:

Symeonidi D, Koumoundouros G., Flytzanis C. N., and Klapa M. I., "Full-genome transcriptomic analysis of thermally induced gene expression in zebrafish larvae",


which received a best poster presentation award at the 2010 Conference of the Hellenic Society for Computational Biology & Bioinformatics, October 17-19, Alexandroupoli, Greece, was recently (January 27, 2011) selected and evaluated by Christos Ouzounis, a Member of the Faculty of 1000 (F1000), which places the work in the F1000 library of the top 2% of published articles in biology and medicine. The F1000 service is widely used to find significant new research articles. The inclusion of this article in the evaluated ones should significantly increase its visibility.

According to the evaluation: "This is an interesting report on the thermal biology of a key model species, the zebrafish (Danio rerio), and, more specifically, the response of gene expression to developmental temperature during ontogenesis. It will be interesting to find out how these observations relate to similar experiments for other model fish species that are currently under way."

For more information please contact with:
Dr. Maria Klapa, Principal Researcher of FORTH/ICE-HT
Tel.: +30 2610-965249

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